Cat. No. 4865
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclo
Biological ActivityAllosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982. PMID: 23086298.
Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687. PMID: 19079236.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses APY 29 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: APY 29, supplier, APY29, inhibits, IRE1a, IRE1alpha, IRE1α, endoribonuclease, RNase, activates, autophosphorylation, auto, phosphorylation, esterases, inhibitors, activators, ER-stress, Tocris Bioscience, IRE1 products
Find multiple products by catalog number
New Products in this Area
Selective endothelial lipase inhibitor; orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.