Cat. No. 4865
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclo
Biological ActivityAllosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982. PMID: 23086298.
Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687. PMID: 19079236.
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Keywords: APY 29, supplier, APY29, inhibits, IRE1a, IRE1alpha, IRE1α, endoribonuclease, RNase, activates, autophosphorylation, auto, phosphorylation, esterases, inhibitors, activators, ER-stress, Tocris Bioscience, IRE1 products