Cat. No. 4865
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclo
Biological ActivityAllosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982. PMID: 23086298.
Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687. PMID: 19079236.
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Keywords: APY 29, supplier, APY29, inhibits, IRE1a, IRE1alpha, IRE1α, endoribonuclease, RNase, activates, autophosphorylation, auto, phosphorylation, esterases, inhibitors, activators, ER-stress, Tocris Bioscience, IRE1 products