SUN 11602

Cat. No. 4826

SUN 11602 C26H37N5O2 [704869-38-5]

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Chemical Name: 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide

Biological Activity

Basic fibroblast growth factor (bFGF) mimetic. Mimics the neuroprotective effects of bFGF; prevents glutamate-induced neuronal death. Increases levels of CALB1 gene expression in cerebrocortical neurons. Triggers phosphorylation of FGFR, ERK1 and ERK2.

Technical Data

M.Wt:
451.61
Formula:
C26H37N5O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
704869-38-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Murayama et al (2013) SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem.Neurosci. 4 266. PMID: 23421678.

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Keywords: SUN 11602, supplier, SUN11602, basic, fibroblast, growth, factor, bFGF, calcium, binding, protein, calbindin-D28k, Calb, FGFR, receptor, ERK1, ERK2, Tocris Bioscience, FGFR products

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