Borrelidin

Cat. No. 4706

Borrelidin C28H43NO6 [7184-60-3]

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Chemical Name: (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid

Biological Activity

Antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.

Technical Data

M.Wt:
489.64
Formula:
C28H43NO6
Solubility:
Soluble to 2 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
7184-60-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sidhu et al (2015) Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med.Chem.Lett. 6 1122. PMID: 26617965.

Woolard et al (2011) Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms. Chem.Sci. (2) 273. PMID: 22822423.

Kawamura et al (2003) Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. J.Antibiot.(Tokyo). 56 709. PMID: 14563161.

Wakabayashi et al (1997) Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J.Antibiot.(Tokyo). 50 671. PMID: 9315080.

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Keywords: Borrelidin, supplier, antibacterials, antibiotics, threonyl-tRNA, synthetase, ThrRS, antiangiogenics, capillary, capillaries, formation, inhibitors, inhibits, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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