4-CMTB

Cat. No. 4642

4-CMTB C14H15ClN2OS [300851-67-6]

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Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide

Biological Activity

Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Technical Data

M.Wt:
294.8
Formula:
C14H15ClN2OS
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
300851-67-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163. PMID: 21498659.

Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146. PMID: 19719777.

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Keywords: 4-CMTB, supplier, free, fatty, acid, receptors, FFA, FFA2, agonists, positive, allosteric, modulators, pams, Tocris Bioscience, Free Fatty Acid Receptor Agonist products

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