(R)-(+)-Etomoxir sodium salt

Cat. No. 4539

(R)-(+)-Etomoxir sodium salt C15H18ClNaO4 [828934-41-4]

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Chemical Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

Biological Activity

Inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data

M.Wt:
320.74
Formula:
C15H18ClNaO4
Solubility:
Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
828934-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 44 415. PMID: 12576524.

Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 6 2349. PMID: 1531968.

Agius et al (1991) Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 42 1717. PMID: 1930298.

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Keywords: (R)-(+)-Etomoxir sodium salt, supplier, carnitine, o-palmitoyltransferase, acyltransferases, I, CPT1, inhibitors, inhibits, Tocris Bioscience, Other Transferase Inhibitor products

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