Cat. No. 3973
Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo
Biological ActivityReversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376. PMID: 10854330.
Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120. PMID: 10859320.
Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171.
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Citations are publications that use Tocris products. Selected citations for Latrunculin A include:
Oenema et al (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget 8 e65580. PMID: 23840342.
Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173. PMID: 25569349.
Suzuki et al (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron 5 16874. PMID: 26575097.
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Keywords: Latrunculin A, supplier, inhibits, inhibitors, actin, assembly, actin, polymerization, polymerisation, LatrunculinA, Tocris Bioscience, Actin Inhibitor products
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October 30 - November 3, 2016
Boston, MA, USA