Latrunculin A

Cat. No. 3973

Latrunculin A C22H31NO5S [76343-93-6]

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Chemical Name: 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone

Biological Activity

Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

Technical Data

M.Wt:
421.55
Formula:
C22H31NO5S
Solubility:
Soluble to 10 mM in DMSO
Storage:
Store at -20°C
CAS No:
76343-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

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References are publications that support the products' biological activity.

Morton et al (2000) Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2 376. PMID: 10854330.

Yarmola et al (2000) Actin-latrunculin A structure and function. J.Biol.Chem. 275 28120. PMID: 10859320.

Blasberger et al (1989) On the chemistry of latrunculins A and B. Liebigs.Ann.Chem. 1989 1171.

If you know of a relevant reference for Latrunculin A please let us know.

Citations are publications that use Tocris products. Selected citations for Latrunculin A include:

Han et al (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature 539 570. PMID: 27820945.

Oenema et al (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget 8 e65580. PMID: 23840342.

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173. PMID: 25569349.

Suzuki et al (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron 5 16874. PMID: 26575097.

Arash et al (2014) Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J 33 2997. PMID: 25425573.

Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci 126 2955. PMID: 23659999.

Do you know of a great paper that uses Latrunculin A from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Latrunculin A, supplier, inhibits, inhibitors, actin, assembly, actin, polymerization, polymerisation, LatrunculinA, Tocris Bioscience, Actin Inhibitor products

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