Cat. No. 3907
Alternative Names: 27 OHC, 27 HC
Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol
Biological ActivityLiver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
DuSell et al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65. PMID: 17872378.
Rantham Prabhakara et al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722. PMID: 19014385.
Fu et al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378. PMID: 11504730.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses 27-Hydroxycholesterol from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 27-Hydroxycholesterol, supplier, 27OHC, 27HC, liver-x, receptors, agonists, estrogen, partial, SERM, selective, modulators, cholesterol, Tocris Bioscience, LXR-like Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Synthetic retinoid; induces differentiation of stem cellsSI-2 hydrochloride
Steroid receptor coactivator 3 (SRC-3) inhibitorSR 0987
T cell-specific RORγ (RORγt) agonistWAY 252623
Potent LXR agonistSR 9009
Rev-Erbα/β agonistSR 9238
Potent and selective LXR inverse agonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.