27-Hydroxycholesterol

Cat. No. 3907

27-Hydroxycholesterol C27H46O2 [20380-11-4]

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Alternative Names: 27 OHC, 27 HC

Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol

Biological Activity

Liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Technical Data

M.Wt:
402.65
Formula:
C27H46O2
Solubility:
Soluble to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
20380-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

DuSell et al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65. PMID: 17872378.

Rantham Prabhakara et al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722. PMID: 19014385.

Fu et al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378. PMID: 11504730.

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Keywords: 27-Hydroxycholesterol, supplier, 27OHC, 27HC, liver-x, receptors, agonists, estrogen, partial, SERM, selective, modulators, cholesterol, Tocris Bioscience, LXR-like Receptor Agonist products

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