Cortistatin 14

Cat. No. 3374

Cortistatin 14 Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys
Disulfide bridge: 2,13

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Biological Activity

Endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Technical Data

M.Wt:
1721.03
Formula:
C81H113N19O19S2
Sequence:
PCKNFFWKTFSSCK

(Modifications: Disulfide bridge between 2 - 13)

Solubility:
Soluble to 0.70 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
193829-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1. PMID: 11227737.

Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228.

Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157.

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Keywords: Cortistatin 14, supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, Tocris Bioscience, Somatostatin (sst) Receptor products

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