Cat. No. 3374
Biological ActivityEndogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
(Modifications: Disulfide bridge between 2 - 13)
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1. PMID: 11227737.
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228.
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157.
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Keywords: Cortistatin 14, supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, Tocris Bioscience, Somatostatin (sst) Receptor products
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