Cat. No. 3374
Biological ActivityEndogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 5, 0.09, 0.3, 0.2 and 0.3 nM at sst1, sst2, sst3, sst4 and sst5 receptors respectively). Also binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
(Modifications: Disulfide bridge between 2 - 13)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1. PMID: 11227737.
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228.
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Cortistatin 14 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Cortistatin 14, supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, Tocris Bioscience, Somatostatin (sst) Receptor products
Find multiple products by catalog number
New Products in this Area
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonistNeuropeptide S (Mouse)
Potent endogenous neuropeptide S receptor (NPSR) agonistML 382
MrgX1 (SNSR4) positive allosteric modulatorK-(D-1-Nal)-FwLL-NH2
High affinity and potent ghrelin receptor inverse agonistNeuropeptide S (Rat)
Potent endogenous neuropeptide S receptor agonistNeuropeptide S (human)
Potent endogenous neuropeptide S receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.