Cat. No. 0782

2-CMDO C19H19ClN2O.C4H4O4 [24140-98-5]

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Chemical Name: 2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate

Biological Activity

Dopamine D2-like receptor antagonist that displays some selectivity for D4 receptors (Ki values are 0.54 and 2.5 nM for D4 and D2 receptors respectively).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zawilska et al (2003) L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors. J.Neural Transm. 110 219. PMID: 12658371.

Phillips et al (1995) Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of clozapine to dopamine and serotonin receptors. J.Med.Chem. 38 708. PMID: 7861418.

Phillips et al (1994) Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of clozapine to dopamine and serotonin receptors. J.Med.Chem. 37 2686. PMID: 8064797.

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Citations are publications that use Tocris products.

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Keywords: 2-CMDO, supplier, D2-like, antagonists, Displays, D4, selectivity, Dopamine, Non-Selective, Receptors, dopaminergic, 2-Chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin, maleate, Tocris Bioscience, Non-selective Dopamine Antagonist products

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