Castanospermine

Cat. No. 0759

Castanospermine C8H15NO4 [79831-76-8]

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Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol

Biological Activity

Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Technical Data

M.Wt:
189.21
Formula:
C8H15NO4
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in water
Storage:
Store at RT
CAS No:
79831-76-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74. PMID: 2959866.

Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120. PMID: 2825177.

Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668. PMID: 6424575.

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Keywords: Castanospermine, supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, inhibits, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism, Tocris Bioscience, Glycosylase Inhibitor products

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