Cat. No. 3231
Biological ActivityN-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
(Modifications: Gln-1 = N-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rabiert et al (2007) The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview. Biochimie 89 1089. PMID: 17428601.
Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762.
Walther et al (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol.Cell 5 831. PMID: 10882119.
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Keywords: Ac9-25, supplier, Annexin, I, N-terminal, peptide, Acts, FPR1, ligands, FPRL, Formyl, Peptide, Receptors, Tocris Bioscience, Formyl Peptide Receptor Ligand products
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