Cat. No. 3224
Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Penta
Biological ActivityPure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers. J.Steroid Molec.Biol. 92 1.
Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263. PMID: 9443403.
Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449.
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Keywords: RU 58668, supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Tocris Bioscience, Estrogen and Related Receptor products