RU 58668

Cat. No. 3224

RU 58668 C34H43F5O5S [151555-47-4]

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Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol

Biological Activity

Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.

Technical Data

M.Wt:
658.76
Formula:
C34H43F5O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>95 %
Storage:
Store at +4°C
CAS No:
151555-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ameller et al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers. J.Steroid Molec.Biol. 92 1.

Muller et al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263. PMID: 9443403.

Van de Velde et al (1996) RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59 449.

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Keywords: RU 58668, supplier, RU58668, pure, antiestrogen, antioestrogen, estrogen, receptors, ER, Tocris Bioscience, Estrogen and Related Receptor products

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