Resiniferatoxin

Cat. No. 1137

Resiniferatoxin C37H40O9 [57444-62-9]

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Chemical Name: 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR) -3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate

Biological Activity

Potent analog of capsaicin that is an agonist at vanilloid receptors (Ki = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.

Technical Data

M.Wt:
628.72
Formula:
C37H40O9
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
57444-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Acs et al (1996) Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res.Mol.Brain Res. 35 173. PMID: 8717353.

Szolcsanyi et al (1990) Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J.Pharmacol.Exp.Ther. 255 923. PMID: 2243359.

Winter et al (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 520 131. PMID: 2169951.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Resiniferatoxin include:

Graham et al (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. J Cell Sci 126 4602. PMID: 23943873.

Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. J Pharmacol Exp Ther 7 4. PMID: 21219650.

Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1. PMID: 19907129.

Yuan and Burrell (2010) Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. J Neurophysiol 104 2766. PMID: 20884761.

Do you know of a great paper that uses Resiniferatoxin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Resiniferatoxin, supplier, Ultrapotent, vanilloid, receptor, agonist, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Tocris Bioscience, TRPV Agonist products

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