ZM 306416 hydrochloride
Cat. No. 2499
Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-
Biological ActivityInhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369. PMID: 10639280.
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Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:
Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528. PMID: 25788671.
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182. PMID: 25307081.
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Keywords: ZM 306416 hydrochloride, supplier, inhibitors, inhibits, receptors, tyrosine, kinase, VEGFR, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, RTKs, ZM306416, hydrochloride, AstraZeneca, Tocris Bioscience, VEGFR Inhibitor products
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