ZM 306416 hydrochloride

Cat. No. 2499

ZM 306416 hydrochloride C16H13N3O2FCl.HCl [196603-47-1]

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Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride

Biological Activity

Inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
370.21
Formula:
C16H13N3O2FCl.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
196603-47-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369. PMID: 10639280.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:

Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528. PMID: 25788671.

Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182. PMID: 25307081.

Do you know of a great paper that uses ZM 306416 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: ZM 306416 hydrochloride, supplier, inhibitors, inhibits, receptors, tyrosine, kinase, VEGFR, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, RTKs, ZM306416, hydrochloride, AstraZeneca, Tocris Bioscience, VEGFR Inhibitor products

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