Amyloid β-peptide (1-42) (rat)

Cat. No. 2425

Amyloid b-peptide (1-42) (rat) Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

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Biological Activity

Rat form of the predominant amyloid β-peptide found in plaques associated with Alzheimer's disease. Leads to a large shift in the bax/bcl-2 ratio in favour of pro-apoptotic bax. Neurotoxic.

Technical Data

M.Wt:
4417.99
Formula:
C199H307N53O59S
Sequence:
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Solubility:
Soluble to 1 mg/ml in 0.1% Ammonia
Storage:
Desiccate at -20°C
CAS No:
166090-74-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Clementi et al (2006) Alzheimer's amyloid β-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35. Biochem.Biophys.Res.Comm. 342 206.

Van Nostrand et al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297. PMID: 8624102.

Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Comm. 120 885.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Amyloid β-peptide (1-42) (rat) include:

Yulei et al (2016) Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer's Disease Journal of Alzheimer's Disease 53 1419. PMID: 27372643.

Do you know of a great paper that uses Amyloid β-peptide (1-42) (rat) from Tocris? If so please let us know.

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