Cat. No. 2193
Alternative Name: EMD 45609
Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-py
Biological ActivitySelective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Rump et al (1993) Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices. Eur.J.Clin.Pharmacol. 44 S47. PMID: 8097997.
Haeusler et al (1992) Pharmacological basis for antihypertensive therapy with a novel dopamine agonist Eur.Heart J. 13 129. PMID: 1356783.
Hasse et al (1991) Neurochemical profile of EMD 45609 (carmoxirole), a dopamine DA2-receptor agonist. Naunyn-Schmied.Arch.Pharmacol. 343 588.
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Citations are publications that use Tocris products. Selected citations for Carmoxirole hydrochloride include:
Schlenker et al (2014) Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression. Respir Physiol Neurobiol 193 29. PMID: 24434437.
Schlenker and Schultz (2012) Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain. Respir Physiol Neurobiol 180 69. PMID: 22051191.
Do you know of a great paper that uses Carmoxirole hydrochloride from Tocris? If so please let us know.
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Keywords: Carmoxirole hydrochloride, supplier, Selective, peripherally, peripheral, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, EMD45609, Tocris Bioscience, Non-selective Dopamine Agonist products