Carmoxirole hydrochloride

Cat. No. 2193

Carmoxirole hydrochloride C24H26N2O2.HCl [115092-85-8]

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Alternative Name: EMD 45609

Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole-5-carboxylic acid hydrochloride

Biological Activity

Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rump et al (1993) Dopamine receptor modulation of noradrenaline release by carmoxirole in human cortical kidney slices. Eur.J.Clin.Pharmacol. 44 S47. PMID: 8097997.

Haeusler et al (1992) Pharmacological basis for antihypertensive therapy with a novel dopamine agonist Eur.Heart J. 13 129. PMID: 1356783.

Hasse et al (1991) Neurochemical profile of EMD 45609 (carmoxirole), a dopamine DA2-receptor agonist. Naunyn-Schmied.Arch.Pharmacol. 343 588.

If you know of a relevant reference for Carmoxirole hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Carmoxirole hydrochloride include:

Schlenker et al (2014) Hypothyroidism affects D2 receptor-mediated breathing without altering D2 receptor expression. Respir Physiol Neurobiol 193 29. PMID: 24434437.

Schlenker and Schultz (2012) Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain. Respir Physiol Neurobiol 180 69. PMID: 22051191.

Do you know of a great paper that uses Carmoxirole hydrochloride from Tocris? If so please let us know.

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Keywords: Carmoxirole hydrochloride, supplier, Selective, peripherally, peripheral, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, EMD45609, Tocris Bioscience, Non-selective Dopamine Agonist products

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