Cat. No. 1104
Chemical Name: 1-[2-Chloro-6-[[(3-iodophenyl)methy
Biological ActivityHigh affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.
Licensing InformationSold with the permission of the NIH, US Patent 08/091,109
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jacobson (1998) Adenosine A3 receptors: novel ligands and paradoxical effects. TiPS 19 184. PMID: 9652191.
Schaick et al (1996) Hemodynamic effects of histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats. Eur.J.Pharmacol. 308 311. PMID: 8858305.
Kim et al (1994) 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. J.Med.Chem. 37 3614. PMID: 7932588.
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Citations are publications that use Tocris products. Selected citations for 2-Cl-IB-MECA include:
Vincenzi et al (2013) Pulsed electromagnetic fields increased the anti-inflammatory effect of A2A and A3 adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS One 8 e65561. PMID: 23741498.
Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338. PMID: 22787201.
Montinaro et al (2012) Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. PLoS One 7 e45401. PMID: 23028986.
Germack and Dickenson (2004) Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol 141 329. PMID: 14751870.
Man et al (2003) Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol 139 172. PMID: 12746236.
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Keywords: 2-Cl-IB-MECA, supplier, selective, A3, agonists, Receptors, adenosines, 2ClIBMECA, Tocris Bioscience, A3 Receptor Agonist products