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Submit ReviewJNJ 10198409
说明： Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
化学名： N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
纯度： ≥98% (HPLC)
生物活性 for JNJ 10198409
JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)
许可信息
Sold with the permission of Janssen Pharmaceutica N.V.
化合物库 for JNJ 10198409
JNJ 10198409 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for JNJ 10198409
| 分子量 | 325.34 |
| 公式 | C18H16FN3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 627518-40-5 |
| PubChem ID | 9797370 |
| InChI Key | ZDNURMVOKAERHZ-UHFFFAOYSA-N |
| Smiles | COC1=C(OC)C=C2C(CC3=C2NN=C3NC2=CC(F)=CC=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JNJ 10198409
参考文献 for JNJ 10198409
参考文献是支持产品生物活性的出版物。
Ho et al (2005) (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 29 8163 PMID: 16366598
Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 352 1216 PMID: 27127239
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关键词: JNJ 10198409, JNJ 10198409 supplier, JNJ10198409, stem, cell, reprogramming, 9C, cocktail, cardiomyocytes, myocytes, platelet-derived, growth, factor, receptor, alpha, beta, inhibitors, inhibits, PDGFR, PDGFRb, PDGFRa, transdifferentiation, Src, Kinases, Other, Stem, Cell, Reprogramming, Cardiomyocyte, Cells, 6976, Tocris Bioscience
8 篇 JNJ 10198409 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JNJ 10198409 的部分引用包括：
Stephen H et al (2016) Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway. PLoS One 11 e0161445 PMID: 27776132
Anisur et al (2014) Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway. Dev Cell 31 747-60 PMID: 25482883
Donghong et al (2020) Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor. Mol Pharmacol 97 123-131 PMID: 31734646
Zhihui et al (2011) Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem 286 39450-6 PMID: 21956113
Stewart O et al (2015) Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets. Cell Calcium 58 577-88 PMID: 26434503
Q Jane et al (2013) Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1. J Biol Chem 288 37343-54 PMID: 24265314
Ulrich et al (2019) Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth. Elife 8 PMID: 31526478
F et al (2000) Protein kinase C activity modulates dendritic differentiation of rat Purkinje cells in cerebellar slice cultures. Eur J Neurosci 12 1993-2005 PMID: 10886339
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