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NX 1607

Cat. No. 8950 Submit a Review Datasheet / COA / SDS
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Description: CBL-B intramolecular glue inhibitor
Chemical Name: 2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NX 1607

NX 1607 (Cbl-b-IN-3) is an inhibitor of CBL-B (Casitas B-lineage lymphoma proto-oncogene B), a RING-type E3 ubiquitin ligase. NX 1607 acts as an intramolecular glue. In vitro, NX 1607 activates MAPK/ERK signaling pathway and enhances T-cell activation in primary T cells and Jurkat T cells. In vivo, NX 1607 decreases tumor growth in cell lymphoma models. NX 1607 is orally bioavailable.

Licensing Information

Sold under license from Nurix Therapeutics

Technical Data for NX 1607

M. Wt 537.63
Formula C30H34F3N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2573775-59-2
PubChem ID 155449671
InChI Key HUOLMBXGHHSYHC-QWQFASRJSA-N
Smiles CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NX 1607

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.75 20
ethanol 53.76 100

Preparing Stock Solutions for NX 1607

The following data is based on the product molecular weight 537.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.3 mL 18.6 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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References for NX 1607

References are publications that support the biological activity of the product.

Zhu et al (2025) Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation. J.Immunother.Cancer 13 e011180 PMID: 40447319

If you know of a relevant reference for NX 1607, please let us know.

View Related Products by Target

Keywords: NX 1607, NX 1607 supplier, NX1607, NX-1607, Cbl-b-IN-3, E3, ubiquitin, ligase, intramolecular, glue, in, vivo, orally, bioavailable, lymphoma, MAPK/ERK, signaling, pathway, T-cell, activation, Ubiquitin, Ligases, Molecular, Glues, 8950, Tocris Bioscience

Citations for NX 1607

Citations are publications that use Tocris products.

Currently there are no citations for NX 1607. Do you know of a great paper that uses NX 1607 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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