Scientific Reviews

A range of review articles written by leading experts

Tocris produces a range of short review articles written by leading experts summarizing the most recent developments in research and available products. We invite you to request or download your copy today.

5-HT Receptors

Neuronal 5-HT Receptors and SERT

Nicholas M. Barnes and John F. Neumaier

This review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in physiological and pharmacological processes. Compounds available from Tocris are listed.

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5-HT Receptors Scientific Review

Autophagy

Molecular Mechanisms, Physiology & Pathology

Patricia Boya and Patrice Codogno

This review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

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Autophagy Scientific Review

Cannabinoid Receptor Ligands

Roger G Pertwee, University of Aberdeen

Two types of cannabinoid receptor have so far been identified. This review focuses particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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Cannabinoid Receptor Ligands Scientific Review

Dopamine Receptors

Phillip G. Strange & Kim Neve

Revised in 2013, this review summarizes the history of the dopamine receptor subtypes and provides a guide to the ligands that act upon them. Compounds available from Tocris are listed.

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Dopamine Receptors Scientific Review

Epigenetics

Epigenetic Probes: Open Access Drug Discovery

Susanne Müller-Knapp and Peter J. Brown

This review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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Epigenetics Scientific Review

Peptides Involved in Appetite Modulation

Sonia A. Tucci, Lynsay Kobelis and Tim C. Kirkham, University of Liverpool

A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis, outlining the putative roles of most of the known proteins and lists compounds available from Tocris.

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Peptides Involved in Appetite Modulation Scientific Review

GABA Receptors

Ian Martin, Norman Bowery & Susan Dunn

A review of the structure and function of GABA receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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GABA Receptors Scientific Review

Histamine Receptors

Iwan de Esch and Rob Leurs, Vrije University

This review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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Histamine Receptors Scientific Review

MAPK Signaling

Functions and Modulation of MAP Kinase Pathways

Elma Zaganjor and Melanie H. Cobb, University of Texas Southwestern Medical Center

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer research. This review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

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MAPK Signaling Scientific Review

Metabotropic Glutamate Receptors

Francine C Acher, Université René Descartes-Paris V

Glutamate is the major excitatory amino acid transmitter in the brain. This review explains the pharmacology of mGlu receptors and the compounds acting upon them, listing those mGlu compounds available from Tocris.

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Metabotropic Glutamate Receptors Scientific Review

Nicotinic ACh Receptors

Susan Wonnacott, University of Bath

Updated in 2014, this review summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Nicotinic ACh Receptors Scientific Review

P2X and P2Y Receptors

Kenneth A. Jacobson, National Institutes of Health

A review of the subtypes and structures of P2 receptor families and the pharmacological probes used to study them. Compounds available from Tocris are listed.

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P2X and P2Y Receptors Scientific Review

Retinoid Receptors

Pharmacology of Retinoid Receptors

Alexander R. Moise, University of Kansas

A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Compounds available from Tocris are listed.

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Retinoid Receptors Scientific Review

Stem Cells

Using Small Molecules to Control Stem Cell Growth and Differentiation

Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, Durham University

This review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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Stem Cells Scientific Review

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Physiology 2016

Physiology 2016

July 29 - 31, 2016

Dublin, Ireland

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