Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 228.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.38 mL||21.9 mL||43.8 mL|
|5 mM||0.88 mL||4.38 mL||8.76 mL|
|10 mM||0.44 mL||2.19 mL||4.38 mL|
|50 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the products' biological activity.
Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID: 27326330
Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID: 26962172
If you know of a relevant reference for ZQ 16, please let us know.
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Keywords: ZQ 16, supplier, ZQ16, selective, medium, chain, free, fatty, acid, receptor, GPR84, agonists, agonism, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience
1 Citation for ZQ 16
Citations are publications that use Tocris products. Selected citations for ZQ 16 include:
Sundqvist (2018) Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta 1865 695 PMID: 29477577
Do you know of a great paper that uses ZQ 16 from Tocris? If so please let us know.
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Literature in this Area
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