ZQ 16

Pricing Availability   Qty
Cat.No. 6001 - ZQ 16 | C10H16N2O2S | CAS No. 376616-73-8
Description: Selective GPR84 agonist
Chemical Name: 2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.

Technical Data

M. Wt 228.31
Formula C10H16N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 376616-73-8
PubChem ID 1912564
InChI Key UYXOAKRMLQKLQX-UHFFFAOYSA-N
Smiles CCCCCCSC1=NC(O)=CC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.42 50
ethanol 22.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 228.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.9 mL 43.8 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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References

References are publications that support the biological activity of the product.

Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID: 27326330

Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID: 26962172


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Keywords: ZQ 16, ZQ 16 supplier, ZQ16, selective, medium, chain, free, fatty, acid, receptor, GPR84, agonists, agonism, Free, Fatty, Acid, Receptors, 6001, Tocris Bioscience

1 Citation for ZQ 16

Citations are publications that use Tocris products. Selected citations for ZQ 16 include:

Sundqvist (2018) Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta 1865 695 PMID: 29477577


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Literature in this Area

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