Zamifenacin fumarate

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Cat.No. 2579 - Zamifenacin fumarate | C27H29NO3.C4H4O4 | CAS No. 127308-98-9
Description: Selective M3 antagonist
Alternative Names: UK 76654
Chemical Name: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective M3 muscarinic receptor antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively). Displays higher affinity at ileal M3 receptors (pKi = 9.3) compared to oesophageal and tracheal M3 receptors (pKi values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects.

Compound Libraries

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Technical Data

M. Wt 531.6
Formula C27H29NO3.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 127308-98-9
PubChem ID 20056967
InChI Key PMHKTAIGYOVZEZ-ZHWJIHCSSA-N
Smiles C1(CCN3C[C@H](OC(C5=CC=CC=C5)C4=CC=CC=C4)CCC3)=CC=C(OCO2)C2=C1.C(\C=C\C(O[H])=O)(O[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.16 100
ethanol 13.29 25

Preparing Stock Solutions

The following data is based on the product molecular weight 531.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.41 mL 18.81 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wallis (1995) Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists. Life Sci. 56 861 PMID: 10188786

Watson et al (1995) Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur.J.Pharmacol. 285 135 PMID: 8566131

Choppin (2002) Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains. Br.J.Pharmacol. 137 522 PMID: 12359634


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Keywords: Zamifenacin fumarate, supplier, Selective, M3, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, UK76654, UK, 76654, M3, Receptors, Tocris Bioscience

Citations for Zamifenacin fumarate

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