YZ9

Pricing Availability Delivery Time Qty
Cat.No. 5048 - YZ9 | C12H10O5 | CAS No. 6093-71-6
Description: PFKFB3 inhibitor
Chemical Name: Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.

Compound Libraries

YZ9 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 234.2
Formula C12H10O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6093-71-6
PubChem ID 5289613
InChI Key IETDBZQIWIJQJG-UHFFFAOYSA-N
Smiles O=C2C(C(OCC)=O)=CC1=CC=C(O)C=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.71 50
ethanol 4.68 20

Preparing Stock Solutions

The following data is based on the product molecular weight 234.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.35 mL 42.7 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Seo et al (2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6 e24179 PMID: 21957443


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Citations for YZ9

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Literature in this Area

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Kinases Product Listing

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for YZ9

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