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Cat.No. 5048 - YZ9 | C12H10O5 | CAS No. 6093-71-6
Description: PFKFB3 inhibitor
Chemical Name: Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.

Technical Data

M. Wt 234.2
Formula C12H10O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6093-71-6
PubChem ID 5289613
Smiles O=C2C(C(OCC)=O)=CC1=CC=C(O)C=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.71 50
ethanol 4.68 20

Preparing Stock Solutions

The following data is based on the product molecular weight 234.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.54 mL 42.7 mL 85.4 mL
2.5 mM 1.71 mL 8.54 mL 17.08 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
25 mM 0.17 mL 0.85 mL 1.71 mL

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References are publications that support the biological activity of the product.

Seo et al (2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6 e24179 PMID: 21957443

If you know of a relevant reference for YZ9, please let us know.

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Keywords: YZ9, YZ9 supplier, PFKFB3, inhibitors, inhibits, phosphofructo, kinase, fructose, bifunctional, enzymes, growth, cancer, glycolysis, warburg, 5048, Tocris Bioscience

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Cell Cycle & DNA Damage Repair

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