YM 750

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Cat.No. 3039 - YM 750 | C31H36N2O | CAS No. 138046-43-2
Description: ACAT inhibitor
Chemical Name: N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data

M. Wt 452.63
Formula C31H36N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 138046-43-2
PubChem ID 9911716
InChI Key FMLJREWZCZHGGW-UHFFFAOYSA-N
Smiles O=C(NC5=C(C)C=C(C)C=C5C)N(C4CCCCCC4)CC3=CC2=C(C=C3)C1=CC=CC=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.26 100
ethanol 4.53 10

Preparing Stock Solutions

The following data is based on the product molecular weight 452.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.09 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nagata et al (1995) N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 49 643 PMID: 7887979

Kamiya et al (2000) Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 48 817 PMID: 10866142

Miike et al (2008) Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 82 79 PMID: 18037448


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Keywords: Acyl-CoA:cholesterol acyltransferase ACAT inhibitors inhibits transferase YM750 Acyl-CoA:Cholesterol Acyltransferase

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