XR 9051 HCl

Discontinued Product

XR 9051 HCl (Cat. No. 2944) has been withdrawn from sale for commercial reasons.
Description: Potent modulator of P-gp-mediated MDR
Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamide hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for XR 9051 HCl

Potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Reverses resistance to a variety of cytotoxic drugs (including doxorubicin, etoposide and vincristine) in several murine and human P-gp-overexpressing cell lines. Orally active.

Technical Data for XR 9051 HCl

M. Wt 679.2
Formula C39H38N4O5.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 180422-22-4
Smiles O=C(C3=CC=CC(/C=C5\NC(/C(N(C)C5=O)=C/C4=CC=CC=C4)=O)=C3)NC(C=C2)=CC=C2CCN1CC(C=C(OC)C(OC)=C6)=C6CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for XR 9051 HCl

References are publications that support the biological activity of the product.

Dale et al (1998) Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative. Br.J.Cancer 78 885 PMID: 9764579

Mistry et al (1999) In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance. Br.J.Cancer 79 1672 PMID: 10206276

Martin et al (2000) Communication between multidrug binding sites on P-glycoprotein. Mol.Pharmacol. 58 624 PMID: 10953057

View Related Products by Target

View Related Products by Product Action

View all Multidrug Transporter Modulators

Keywords: XR 9051 HCl, XR 9051 HCl supplier, Potent, modulators, P-gp-mediated, MDR, P-glycoprotein, Resistance, Protein, Multidrug, Transporters, XR9051, ABCB1, 2944, Tocris Bioscience

Citations for XR 9051 HCl

Citations are publications that use Tocris products.

Currently there are no citations for XR 9051 HCl.

Reviews for XR 9051 HCl

There are currently no reviews for this product. Be the first to review XR 9051 HCl and earn rewards!

Have you used XR 9051 HCl?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.