XMD 8-87

Pricing Availability   Qty
Cat.No. 6061 - XMD 8-87 | C24H27N7O2 | CAS No. 1234480-46-6
Description: Potent Ack1/TNK2 inhibitor
Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity for XMD 8-87

XMD 8-87 is a potent Ack1/TNK2 inhibitor (IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data for XMD 8-87

M. Wt 445.52
Formula C24H27N7O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1234480-46-6
PubChem ID 53322923
Smiles COC1=C(C=CC(N2CCN(CC2)C)=C1)NC3=NC=C4NC(C5=CC=CC=C5N(C4=N3)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XMD 8-87

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 44.55 100
DMSO 22.28 50

Preparing Stock Solutions for XMD 8-87

The following data is based on the product molecular weight 445.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References for XMD 8-87

References are publications that support the biological activity of the product.

Maxson et al (2015) Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis. Cancer.Res. 76 127 PMID: 26677978

Maxson et al (2014) Development and repurposing of small-molecule kinase inhibitors to target novel leukemogenic TNK2 mutations Blood 124 435

If you know of a relevant reference for XMD 8-87, please let us know.

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Keywords: XMD 8-87, XMD 8-87 supplier, XMD8-87, Inhibitors, inhibits, Ack1, TNK2, Ba/F3, leukemia, D163E, R806Q, phosphorylation, tyrosine, kinase, 2, 6061, Tocris Bioscience

Citations for XMD 8-87

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