WL 47 - dimer

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Cat.No. 5978 - WL 47 - dimer | Lys-Leu-Arg-Met-Trp-Ser-Cys-Cys-Ser-Trp-Met-Arg-Leu-Lys
Description: High affinity caveolin-1 ligand
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity caveolin-1 (CAV1) ligand (Kd = 23 nM); disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL.

Licensing Information

Sold with kind permission of Professor Gregory Weiss

Technical Data

M. Wt 1844.3
Formula C80H130N24O18S4
Sequence CSWMRLK CSWMRLK*

(Modifications: Disulfide Bridge = 1-1*)

Storage Store at -20°C
PubChem ID 123773278
InChI Key DNQUEMNLAOMZEO-HFXGPFCTSA-N
Smiles [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Gilliam et al (2016) Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J.Med.Chem. 59 4019 PMID: 27010220


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Keywords: WL 47 - dimer, WL 47 - dimer supplier, WL47, dimer, high, affinity, selective, caveolin-1, CAV1, ligands, oligomerization, disrupts, Translocation,, Exocytosis, &, Endocytosis, 5978, Tocris Bioscience

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Literature in this Area

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