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Submit ReviewWL 47 - dimer
Discontinued Product
WL 47 - dimer (Cat. No. 5978) has been withdrawn from sale for commercial reasons.
Description: High affinity caveolin-1 ligand
Biological Activity for WL 47 - dimer
WL 47 - dimer is a high affinity caveolin-1 (CAV1) ligand (Kd = 23 nM); disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL.
Licensing Information
Sold with kind permission of Professor Gregory Weiss
Technical Data for WL 47 - dimer
| M. Wt | 1844.3 |
| Formula | C80H130N24O18S4 |
| Sequence |
CSWMRLK CSWMRLK* (Modifications: Disulfide Bridge = 1-1*) |
| Storage | Store at -20°C |
| PubChem ID | 123773278 |
| InChI Key | DNQUEMNLAOMZEO-HFXGPFCTSA-N |
| Smiles | [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WL 47 - dimer
References for WL 47 - dimer
References are publications that support the biological activity of the product.
Gilliam et al (2016) Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J.Med.Chem. 59 4019 PMID: 27010220
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Keywords: WL 47 - dimer, WL 47 - dimer supplier, WL47, dimer, high, affinity, selective, caveolin-1, CAV1, ligands, oligomerization, disrupts, Endocytosis, 5978, Tocris Bioscience
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