WAY 200070

Discontinued Product

WAY 200070 (Cat. No. 3366) has been withdrawn from sale for commercial reasons.
Description: Selective ERβ agonist
Chemical Name: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Pathways (1)

Biological Activity for WAY 200070

WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.

Technical Data for WAY 200070

M. Wt 306.11
Formula C13H8BrNO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 440122-66-7
PubChem ID 9861330
InChI Key IVFWABSHZFOMIG-UHFFFAOYSA-N
Smiles BrC1=C2C(N=C(C3=CC=C(O)C=C3)O2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for WAY 200070

References are publications that support the biological activity of the product.

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777

Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284

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Keywords: WAY 200070, WAY 200070 supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, 3366, Tocris Bioscience

4 Citations for WAY 200070

Citations are publications that use Tocris products. Selected citations for WAY 200070 include:

Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685 PMID: 22698981

Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons. Front Cell Neurosci 9 137 PMID: 25926772

Alonso-Magdalena et al (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One 62 2015 PMID: 23349481

Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008


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Pathways for WAY 200070

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.