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WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246
Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777
Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284
Keywords: WAY 200070, WAY 200070 supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, 3366, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for WAY 200070 include:
Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008
Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685 PMID: 22698981
Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons. Front Cell Neurosci 9 137 PMID: 25926772
Alonso-Magdalena et al (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One 62 2015 PMID: 23349481
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