Selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 306.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.27 mL||16.33 mL||32.67 mL|
|5 mM||0.65 mL||3.27 mL||6.53 mL|
|10 mM||0.33 mL||1.63 mL||3.27 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246
Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777
Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284
If you know of a relevant reference for WAY 200070, please let us know.
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Keywords: WAY 200070, supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
3 Citations for WAY 200070
Citations are publications that use Tocris products. Selected citations for WAY 200070 include:
Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons. Front Cell Neurosci 9 137 PMID: 25926772
Alonso-Magdalena et al (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One 62 2015 PMID: 23349481
Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685 PMID: 22698981
Do you know of a great paper that uses WAY 200070 from Tocris? If so please let us know.