W-84 dibromide

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Cat.No. 0532 - W-84 dibromide | C32H44Br2N4O4 | CAS No. 21093-51-6
Description: Stabilizer of cholinergic antagonist-receptor complexes
Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Reviews (1)
Literature (5)

Biological Activity

Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.

Technical Data

M. Wt 708.53
Formula C32H44Br2N4O4
Storage Store at RT
CAS Number 21093-51-6
PubChem ID 167961
Smiles O=C1N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN(C(C4=C3C=CC=C4)=O)C3=O)C(C2=C1C=CC=C2)=O.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.08 10

Preparing Stock Solutions

The following data is based on the product molecular weight 708.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.11 mL 70.57 mL 141.14 mL
0.5 mM 2.82 mL 14.11 mL 28.23 mL
1 mM 1.41 mL 7.06 mL 14.11 mL
5 mM 0.28 mL 1.41 mL 2.82 mL

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References are publications that support the biological activity of the product.

Jepsen et al (1988) Allosteric stabilisation of [3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol.Toxicol. 63 163 PMID: 3054859

Mitchelson (1975) Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 33 237 PMID: 1242377

Mohr et al (1992) Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 70 198 PMID: 1579545

If you know of a relevant reference for W-84 dibromide, please let us know.

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Keywords: W-84 dibromide, W-84 dibromide supplier, antagonists-receptor, complex, stabilizer, Muscarinic, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0532, Tocris Bioscience

Citations for W-84 dibromide

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HPLC Pharmacokinetic assay.
By Abhijit Nirwane on 01/10/2018
Assay Type: In Vivo
Species: Mouse

Purity is excellent.

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