VULM 1457

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Cat.No. 2988 - VULM 1457 | C25H27N3O3S | CAS No. 228544-65-8
Description: ACAT inhibitor
Chemical Name: N-[2,6-bis(1-Methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats.

Technical Data

M. Wt 449.57
Formula C25H27N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 228544-65-8
PubChem ID 9933427
InChI Key XFFITGBWVLQNCD-UHFFFAOYSA-N
Smiles O=C(NC3=C(C(C)C)C=CC=C3C(C)C)NC(C=C2)=CC=C2SC1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.96 100
ethanol 2.25 5

Preparing Stock Solutions

The following data is based on the product molecular weight 449.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.12 mL 22.24 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Adameova et al (2006) Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats. Pharmazie 61 807 PMID: 17020164

Adameova et al (2007) The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in v Eur.J.Pharmacol. 576 114 PMID: 17764671

Vojtassakova et al (2007) Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet. Gen.Physiol.Biophys. 26 254 PMID: 18281742


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Keywords: Acyl-CoA cholesterol acyltransferase ACAT inhibitors inhibits Transferases VULM1457 Acyl-CoA:Cholesterol Acyltransferase

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