VU 6015929

Pricing Availability   Qty
Description: Potent and selective discoidin domain receptor 1/2 inhibitor
Chemical Name: 4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for VU 6015929

VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC50 = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.

Technical Data for VU 6015929

M. Wt 485.43
Formula C24H19F4N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2442597-56-8
PubChem ID 145925694
Smiles O=C(NC=1C=CC=C(OC(F)(F)F)C1)C2=CC=C(F)C(=C2)NCC3=CN=CC(=C3)C4=NN(C=C4)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 6015929

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.54 100
ethanol 9.71 20

Preparing Stock Solutions for VU 6015929

The following data is based on the product molecular weight 485.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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References for VU 6015929

References are publications that support the biological activity of the product.

Sun (2021) Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 599 673 PMID: 34732895

Jeffries et al (2019) Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 11 29 PMID: 31938459

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Citations for VU 6015929

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