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Biological Activity for VU 6015929
VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC50 = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.
Technical Data for VU 6015929
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 6015929
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for VU 6015929
The following data is based on the product molecular weight 485.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.06 mL||10.3 mL||20.6 mL|
|5 mM||0.41 mL||2.06 mL||4.12 mL|
|10 mM||0.21 mL||1.03 mL||2.06 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
References for VU 6015929
References are publications that support the biological activity of the product.
Sun (2021) Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 599 673 PMID: 34732895
Jeffries et al (2019) Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 11 29 PMID: 31938459
If you know of a relevant reference for VU 6015929, please let us know.
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Citations for VU 6015929
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Literature in this Area
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