Virodhamine

Discontinued Product

Cat.No. 1569 - Virodhamine | C22H37NO2 | CAS No. 287937-12-6
Description: GPR55 and CB2 agonist. CB1 partial agonist/antagonist
Alternative Names: O-Arachidonyl ethanolamine
Chemical Name: O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate
Datasheet
Citations
Literature

Biological Activity

Endogenous cannabinoid receptor mixed agonist/antagonist found in higher concentrations peripherally than anandamide. Full agonist at GPR55 and CB2 and partial agonist/antagonist at CB1 (EC50 values are 12, 381 and 2920 nM at GPR55, CB2 and CB1 receptors respectively). Induces hypothermia in vivo. Also available as part of the Cannabinoid Receptor Agonist Tocriset™ and Endocannabinoid Tocriset™.

Technical Data

M. Wt 347.54
Formula C22H37NO2
Storage Desiccate at -20°C
CAS Number 287937-12-6
Smiles O=C(OCCN)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 347.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.77 mL
5 mM 0.58 mL 2.88 mL 5.75 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Porter et al (2002) Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J.Pharmacol.Exp.Ther. 301 1020 PMID: 12023533

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

Sauer et al (2002) Further characterization of the novel endocannabinoid virodhamine. 2002 Symposium on the Cannabinoids, International PMID:

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Keywords: Virodhamine, supplier, GPR55, CB2, agonists, CB1, partial, antagonists, non-selective, cannabinoids, receptors, cb2r, cb1r, O-Arachidonyl, ethanolamine, Non-selective, Cannabinoids, Non-selective, Cannabinoids, Tocris Bioscience

Citations for Virodhamine

Citations are publications that use Tocris products.

Currently there are no citations for Virodhamine.

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Literature in this Area

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Pathways for Virodhamine

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