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Urocortin (human)

Cat. No. 1604 Submit a Review Datasheet / COA / SDS
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Cat.No. 1604 - Urocortin (human) | Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 | CAS No. 176591-49-4
Description: Endogenous CRF agonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Urocortin (human)

Urocortin (human) is an endogenous CRF agonist. Ki values are 0.4, 0.3 and 0.5 nM for hCRF1, rCRF2α and mCRF2β respectively.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Urocortin (human)

M. Wt 4696.29
Formula C204H337N63O64
Sequence DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

(Modifications: Val-40 = C-terminal amide)
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 176591-49-4
PubChem ID 24868180
InChI Key BIIOOWPFSOAZSO-WODJFTBTSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Urocortin (human)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Urocortin (human)

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Urocortin (human)

References are publications that support the biological activity of the product.

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663

Reul and Holsboer (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr.Opin.Pharmacol. 2 23 PMID: 11786305

Skelton et al (2000) The neurobiology of urocortin. Regul.Pept. 93 85 PMID: 11033056

If you know of a relevant reference for Urocortin (human), please let us know.

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Keywords: Urocortin (human), Urocortin (human) supplier, Endogenous, CRF, agonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Non-selective, 1604, Tocris Bioscience

Citations for Urocortin (human)

Citations are publications that use Tocris products.

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