UNC 2327

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Cat.No. 5057 - UNC 2327 | C14H17N5O2S | CAS No. 1426152-53-5
Description: Allosteric inhibitor of PRMT3
Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Compound Libraries

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Technical Data

M. Wt 319.38
Formula C14H17N5O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1426152-53-5
PubChem ID 71583615
InChI Key MYTRGTBDVGKKRO-UHFFFAOYSA-N
Smiles O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.94 100
ethanol 3.19 10mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 319.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220


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View Related Products by Product Action

View all Protein Arginine Methyltransferase Inhibitors

Keywords: UNC2327 Allosteric inhibitors inhibits protein arginine methyltransferases 3 PRMT3 Protein Arginine Methyltransferases

Citations for UNC 2327

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Literature in this Area

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Epigenetics Scientific Review

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Epigenetics

Epigenetics Research Bulletin

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Pathways for UNC 2327

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