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Description: Allosteric inhibitor of PRMT3
Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Purity: ≥99% (HPLC)
Biological Activity
Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
Compound Libraries
UNC 2327 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 319.38 |
| Formula | C14H17N5O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1426152-53-5 |
| PubChem ID | 71583615 |
| InChI Key | MYTRGTBDVGKKRO-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220
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Keywords: UNC 2327, UNC 2327 supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Protein, Arginine, Methyltransferases, 5057, Tocris Bioscience
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