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Description: Allosteric inhibitor of PRMT3
Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Purity: ≥99% (HPLC)
Biological Activity for UNC 2327
UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
Compound Libraries for UNC 2327
UNC 2327 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for UNC 2327
| M. Wt | 319.38 |
| Formula | C14H17N5O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1426152-53-5 |
| PubChem ID | 71583615 |
| InChI Key | MYTRGTBDVGKKRO-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UNC 2327
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 |
Preparing Stock Solutions for UNC 2327
The following data is based on the product molecular weight 319.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for UNC 2327
References for UNC 2327
References are publications that support the biological activity of the product.
Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220
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Keywords: UNC 2327, UNC 2327 supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Protein, Arginine, Methyltransferases, 5057, Tocris Bioscience
Citations for UNC 2327
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