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UNC 2327

Cat. No. 5057 Submit a Review Datasheet / COA / SDS
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Cat.No. 5057 - UNC 2327 | C14H17N5O2S | CAS No. 1426152-53-5
Description: Allosteric inhibitor of PRMT3
Chemical Name: N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Compound Libraries

UNC 2327 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 319.38
Formula C14H17N5O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1426152-53-5
PubChem ID 71583615
InChI Key MYTRGTBDVGKKRO-UHFFFAOYSA-N
Smiles O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 319.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220

If you know of a relevant reference for UNC 2327, please let us know.

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Keywords: UNC 2327, UNC 2327 supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Protein, Arginine, Methyltransferases, 5057, Tocris Bioscience

Citations for UNC 2327

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