UNC 2327
Biological Activity
Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
Compound Libraries
UNC 2327 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 319.38 |
| Formula | C14H17N5O2S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1426152-53-5 |
| PubChem ID | 71583615 |
| InChI Key | MYTRGTBDVGKKRO-UHFFFAOYSA-N |
| Smiles | O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.94 | 100 | |
| ethanol | 3.19 | 10mM with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220
If you know of a relevant reference for UNC 2327, please let us know.
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Keywords: UNC2327 Allosteric inhibitors inhibits protein arginine methyltransferases 3 PRMT3 Protein Arginine Methyltransferases
Citations for UNC 2327
Citations are publications that use Tocris products.
Currently there are no citations for UNC 2327. Do you know of a great paper that uses UNC 2327 from Tocris? If so please let us know.
Literature in this Area
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