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View all Protein Arginine Methyltransferases products.UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Noncompetitive with both the peptide substrate and cofactor.
UNC 2327 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
M. Wt | 319.38 |
Formula | C14H17N5O2S |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 1426152-53-5 |
PubChem ID | 71583615 |
InChI Key | MYTRGTBDVGKKRO-UHFFFAOYSA-N |
Smiles | O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Liu et al (2013) Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 56 2110 PMID: 23445220
Keywords: UNC 2327, UNC 2327 supplier, UNC2327, Allosteric, inhibitors, inhibits, protein, arginine, methyltransferases, 3, PRMT3, Protein, Arginine, Methyltransferases, 5057, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.