TUG 424

Discontinued Product

TUG 424 (Cat. No. 3795) has been withdrawn from sale for commercial reasons.
Description: FFA1 (GPR40) agonist
Chemical Name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid
Purity: ≥99% (HPLC)

Biological Activity for TUG 424

Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.

Licensing Information

Sold under license from the University of Southern Denmark.

Technical Data for TUG 424

M. Wt 264.32
Formula C18H16O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1082058-99-8
Smiles CC1=CC=CC=C1C#CC2=CC=C(CCC(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TUG 424

References are publications that support the biological activity of the product.

Christiansen et al (2008) Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. J.Med.Chem. 51 7061 PMID: 18947221

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Citations for TUG 424

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Currently there are no citations for TUG 424.

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