TUG 424

Cat. No. 3795 Datasheet / COA / SDS

Discontinued Product

Unfortunately TUG 424 (Cat. No. 3795) has been withdrawn from sale for commercial reasons.
Cat.No. 3795 - TUG 424 | C18H16O2 | CAS No. 1082058-99-8
Description: FFA1 (GPR40) agonist
Chemical Name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid
Purity: ≥99% (HPLC)

Biological Activity

Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.

Licensing Information

Sold under license from the University of Southern Denmark.

Technical Data

M. Wt 264.32
Formula C18H16O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1082058-99-8
Smiles CC1=CC=CC=C1C#CC2=CC=C(CCC(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Christiansen et al (2008) Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. J.Med.Chem. 51 7061 PMID: 18947221

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: TUG 424, supplier, TUG424, free, fatty, acid, receptors, ffa1, GPR40, agonists, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience

Citations for TUG 424

Citations are publications that use Tocris products.

Currently there are no citations for TUG 424.

Reviews for TUG 424

There are currently no reviews for this product. Be the first to review TUG 424 and earn rewards!

Have you used TUG 424?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling