TUG 424

Discontinued Product

TUG 424 (Cat. No. 3795) has been withdrawn from sale for commercial reasons.
Description: FFA1 (GPR40) agonist
Chemical Name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for TUG 424

Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.

Licensing Information

Sold under license from the University of Southern Denmark.

Technical Data for TUG 424

M. Wt 264.32
Formula C18H16O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1082058-99-8
Smiles CC1=CC=CC=C1C#CC2=CC=C(CCC(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TUG 424

References are publications that support the biological activity of the product.

Christiansen et al (2008) Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. J.Med.Chem. 51 7061 PMID: 18947221

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: TUG 424, TUG 424 supplier, TUG424, free, fatty, acid, receptors, ffa1, GPR40, agonists, Free, Fatty, Acid, Receptors, 3795, Tocris Bioscience

Citations for TUG 424

Citations are publications that use Tocris products.

Currently there are no citations for TUG 424.

Reviews for TUG 424

There are currently no reviews for this product. Be the first to review TUG 424 and earn rewards!

Have you used TUG 424?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling