TUG 424

Discontinued Product

Unfortunately TUG 424 (Cat. No. 3795) has been withdrawn from sale for commercial reasons.
Cat.No. 3795 - TUG 424 | C18H16O2 | CAS No. 1082058-99-8
Description: FFA1 (GPR40) agonist
Chemical Name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Agonist of the free fatty acid receptor FFA1 (GPR40) (EC50 = 32 nM). Enhances glucose-stimulated insulin secretion in INS-1E cells at 100 nM.

Licensing Information

Sold under license from the University of Southern Denmark.

Technical Data

M. Wt 264.32
Formula C18H16O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1082058-99-8
Smiles CC1=CC=CC=C1C#CC2=CC=C(CCC(O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.92 mL 37.83 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Christiansen et al (2008) Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. J.Med.Chem. 51 7061 PMID: 18947221

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Citations for TUG 424

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Currently there are no citations for TUG 424.

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for TUG 424

Protocols

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