TT 232

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Cat.No. 4639 - TT 232 | D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2 (Disulfide bridges: 2 - 6) | CAS No. 147159-51-1
Description: sst1/sst4 somatostatin receptor agonist
Datasheet
Citations
Literature

Biological Activity

Peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.

Technical Data

M. Wt 947.13
Formula C45H58N10O9S2
Sequence fCYwKCT

(Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)

Storage Store at -20°C
CAS Number 147159-51-1
PubChem ID 6918265
InChI Key SNAJPQVDGYDQSW-DYCFWDQMSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 947.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.06 mL 5.28 mL 10.56 mL
5 mM 0.21 mL 1.06 mL 2.11 mL
10 mM 0.11 mL 0.53 mL 1.06 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tejeda et al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477 PMID: 17094470

Kéri et al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513 PMID: 8901613

Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545


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Keywords: TT 232, supplier, TT232, sst4, sst1, somatostatin, receptors, analogue, inhibits, tyrosine, kinase, antitumor, antiproliferative, apoptosis, Somatostatin, Receptors, Tocris Bioscience

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