Peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.
(Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 947.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.06 mL||5.28 mL||10.56 mL|
|5 mM||0.21 mL||1.06 mL||2.11 mL|
|10 mM||0.11 mL||0.53 mL||1.06 mL|
|50 mM||0.02 mL||0.11 mL||0.21 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tejeda et al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477 PMID: 17094470
Kéri et al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513 PMID: 8901613
Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545
If you know of a relevant reference for TT 232, please let us know.
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Keywords: TT 232, supplier, TT232, sst4, sst1, somatostatin, receptors, analogue, inhibits, tyrosine, kinase, antitumor, antiproliferative, apoptosis, Somatostatin, Receptors, Tocris Bioscience
Citations for TT 232
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