Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTT 232
Description: sst1 and sst4 agonist
Biological Activity for TT 232
TT 232 is a peptide agonist for sst1/sst4 somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.
Technical Data for TT 232
| M. Wt | 947.13 |
| Formula | C45H58N10O9S2 |
| Sequence |
fCYwKCT (Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 147159-51-1 |
| PubChem ID | 6918265 |
| InChI Key | SNAJPQVDGYDQSW-DYCFWDQMSA-N |
| Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TT 232
References for TT 232
References are publications that support the biological activity of the product.
Tejeda et al (2006) Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 26 3477 PMID: 17094470
Kéri et al (1996) A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 93 12513 PMID: 8901613
Elekes et al (2008) Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 578 313 PMID: 17961545
View Related Products by Target
View Related Products by Product Action
Keywords: TT 232, TT 232 supplier, TT232, sst4, sst1, somatostatin, receptors, analogue, inhibits, tyrosine, kinase, antitumor, antiproliferative, apoptosis, Somatostatin, Receptors, 4639, Tocris Bioscience
Citations for TT 232
Citations are publications that use Tocris products.
Currently there are no citations for TT 232.
Reviews for TT 232
There are currently no reviews for this product. Be the first to review TT 232 and earn rewards!
Have you used TT 232?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image