Inhibitor of acyl-CoA synthetase. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 207.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.82 mL||24.12 mL||48.25 mL|
|5 mM||0.96 mL||4.82 mL||9.65 mL|
|10 mM||0.48 mL||2.41 mL||4.82 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References are publications that support the products' biological activity.
Tomoda et al (1991) Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. J.Biol.Chem. 266 4214 PMID: 1999415
Mashima et al (2005) p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J.Natl.Cancer.Inst. 97 765 PMID: 15900046
If you know of a relevant reference for Triacsin C, please let us know.
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Keywords: Triacsin C, supplier, Triacsin, C, inhibitors, inhibits, acyl-coa-synthetase, antitumor, Other, Synthases/Synthetases, Other, Synthases/Synthetases, Tocris Bioscience
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