Treprostinil

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Description: Potent prostacyclin (PGI2) analog
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Treprostinil

Treprostinil is a potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.

Technical Data for Treprostinil

M. Wt 390.51
Formula C23H34O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 81846-19-7
PubChem ID 6918140
InChI Key PAJMKGZZBBTTOY-ZFORQUDYSA-N
Smiles O[C@H](C3)[C@H](CC[C@@H](O)CCCCC)[C@@]([C@@]3([H])C2)([H])CC1=C2C(OCC(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Treprostinil

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.05 100
ethanol 19.53 50

Preparing Stock Solutions for Treprostinil

The following data is based on the product molecular weight 390.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.8 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for Treprostinil

Certificate of Analysis / Product Datasheet
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References for Treprostinil

References are publications that support the biological activity of the product.

Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, trepros. and iloprost, at human prostanoid receptors: trepros. is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68 PMID: 22480736

Raychaudhuri et al (2002) The prostacyclin analogue trepros. blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344 PMID: 12082102

Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779 PMID: 17533419


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Keywords: Treprostinil, Treprostinil supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Prostanoid, Receptors, 5349, Tocris Bioscience

Citations for Treprostinil

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