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Submit ReviewTreprostinil
Description: Potent prostacyclin (PGI2) analog
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for Treprostinil
Treprostinil is a potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.
Technical Data for Treprostinil
| M. Wt | 390.51 |
| Formula | C23H34O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 81846-19-7 |
| PubChem ID | 6918140 |
| InChI Key | PAJMKGZZBBTTOY-ZFORQUDYSA-N |
| Smiles | O[C@H](C3)[C@H](CC[C@@H](O)CCCCC)[C@@]([C@@]3([H])C2)([H])CC1=C2C(OCC(O)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Treprostinil
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.05 | 100 | |
| ethanol | 19.53 | 50 |
Preparing Stock Solutions for Treprostinil
The following data is based on the product molecular weight 390.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.8 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets for Treprostinil
References for Treprostinil
References are publications that support the biological activity of the product.
Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, trepros. and iloprost, at human prostanoid receptors: trepros. is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68 PMID: 22480736
Raychaudhuri et al (2002) The prostacyclin analogue trepros. blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344 PMID: 12082102
Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779 PMID: 17533419
If you know of a relevant reference for Treprostinil, please let us know.
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Keywords: Treprostinil, Treprostinil supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Prostanoid, Receptors, 5349, Tocris Bioscience
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