Treprostinil

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Cat.No. 5349 - Treprostinil | C23H34O5 | CAS No. 81846-19-7
Description: Potent prostacyclin (PGI2) analog
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.

Technical Data

M. Wt 390.51
Formula C23H34O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 81846-19-7
PubChem ID 6918140
InChI Key PAJMKGZZBBTTOY-ZFORQUDYSA-N
Smiles O[C@H](C3)[C@H](CC[C@@H](O)CCCCC)[C@@]([C@@]3([H])C2)([H])CC1=C2C(OCC(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.05 100
ethanol 19.53 50

Preparing Stock Solutions

The following data is based on the product molecular weight 390.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.8 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68 PMID: 22480736

Raychaudhuri et al (2002) The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344 PMID: 12082102

Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779 PMID: 17533419


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Keywords: Treprostinil, supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

Citations for Treprostinil

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