TRC 051384

Pricing Availability   Qty
Cat.No. 4734 - TRC 051384 | C25H31N5O4 | CAS No. 867164-40-7
Description: Inducer of heat shock protein Hsp70
Chemical Name: N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.

Technical Data

M. Wt 465.54
Formula C25H31N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 867164-40-7
PubChem ID 11634093
InChI Key SQTSPANZQDCPLB-CMDGGOBGSA-N
Smiles O=C(C3=CC=C(NC(NCCN4CCOCC4)=O)C=C3)/C=C/C1=CC=CC(N2CCOCC2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Mohanan et al (2011) Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 60 991 PMID: 21167846


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Keywords: TRC 051384, TRC 051384 supplier, TRC051384, potent, inducers, heat, shock, proteins, HSP70, strokes, neuronal, injury, transient, ischemic, stroke, anti-inflammatory, chaperone, Hsp70, 4734, Tocris Bioscience

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