TRC 051384

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Cat.No. 4734 - TRC 051384 | C25H31N5O4 | CAS No. 867164-40-7
Description: Inducer of heat shock protein Hsp70
Chemical Name: N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.

Technical Data

M. Wt 465.54
Formula C25H31N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 867164-40-7
PubChem ID 11634093

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References are publications that support the biological activity of the product.

Mohanan et al (2011) Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 60 991 PMID: 21167846

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