TRAP-6

Pricing Availability   Qty
Description: PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Alternative Names: Thrombin receptor activator peptide 6
Purity: ≥95% (HPLC)
Datasheet
Citations (8)
Reviews

Biological Activity for TRAP-6

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data for TRAP-6

M. Wt 748.88
Formula C34H56N10O9
Sequence SFLLRN
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 141136-83-6
PubChem ID 9831933
InChI Key HAGOWCONESKMDW-FRSCJGFNSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAP-6

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TRAP-6

Certificate of Analysis / Product Datasheet
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References for TRAP-6

References are publications that support the biological activity of the product.

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429

Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131 PMID: 10421070

Hunter et al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339 PMID: 19261611


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Keywords: TRAP-6, TRAP-6 supplier, PAR1, peptide, fragment, residues, 42-47, agonists, Receptors, Protease-Activated, proteinase-activated, Thrombin, receptor, activator, peptide6, 6, 3497, Tocris Bioscience

8 Citations for TRAP-6

Citations are publications that use Tocris products. Selected citations for TRAP-6 include:

Andreas et al (2013) Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II. Arterioscler Thromb Vasc Biol 33 96-104 PMID: 23117657

Elenbaas et al (2023) SVEP1 is an endogenous ligand for the orphan receptor PEAR1 Nat Commun 14 850 PMID: 36792666

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278

Yan et al (2013) Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Front Bioeng Biotechnol 44 1410 PMID: 23539525


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