TRAP-6

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Cat.No. 3497 - TRAP-6 | Ser-Phe-Leu-Leu-Arg-Asn | CAS No. 141136-83-6
Description: PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Alternative Names: Thrombin receptor activator peptide 6
Datasheet
Citations (2)
Literature

Biological Activity

Peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data

M. Wt 748.88
Formula C34H56N10O9
Sequence SFLLRN
Storage Desiccate at -20°C
CAS Number 141136-83-6
PubChem ID 9831933
InChI Key HAGOWCONESKMDW-FRSCJGFNSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 748.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.68 mL 13.35 mL
5 mM 0.27 mL 1.34 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429

Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131 PMID: 10421070

Hunter et al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339 PMID: 19261611


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2 Citations for TRAP-6

Citations are publications that use Tocris products. Selected citations for TRAP-6 include:

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278

Yan et al (2013) Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Front Bioeng Biotechnol 44 1410 PMID: 23539525


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Literature in this Area

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Pathways for TRAP-6

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