Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Description: PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Alternative Names: Thrombin receptor activator peptide 6
Purity: ≥95% (HPLC)
Citations (5)
Literature (3)

Biological Activity for TRAP-6

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data for TRAP-6

M. Wt 748.88
Formula C34H56N10O9
Sequence SFLLRN
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 141136-83-6
PubChem ID 9831933
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAP-6

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TRAP-6

Certificate of Analysis / Product Datasheet
Select another batch:

References for TRAP-6

References are publications that support the biological activity of the product.

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429

Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131 PMID: 10421070

Hunter et al (2009) Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets. J.Biol.Chem. 284 12339 PMID: 19261611

If you know of a relevant reference for TRAP-6, please let us know.

View Related Products by Product Action

View all Protease-Activated Receptor Agonists

Keywords: TRAP-6, TRAP-6 supplier, PAR1, peptide, fragment, residues, 42-47, agonists, Receptors, Protease-Activated, proteinase-activated, Thrombin, receptor, activator, peptide6, 6, 3497, Tocris Bioscience

5 Citations for TRAP-6

Citations are publications that use Tocris products. Selected citations for TRAP-6 include:

Dhenge et al (2017) Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells. Cell Cycle 16 979 PMID: 28388313

Yan et al (2013) Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Front Bioeng Biotechnol 44 1410 PMID: 23539525

Gockel et al (2018) The Low Molecular Weight HP Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways. Molecules 23 PMID: 30356007

Ponert et al (2018) Unfractionated and Low Molecular Weight HP Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells. Molecules 23 PMID: 30347648

Do you know of a great paper that uses TRAP-6 from Tocris? Please let us know.

Reviews for TRAP-6

There are currently no reviews for this product. Be the first to review TRAP-6 and earn rewards!

Have you used TRAP-6?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.