You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for trans-Ned 19
trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).
Optical Data for trans-Ned 19
|Closest Laser line||355 nm|
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.Spectral Viewer
Technical Data for trans-Ned 19
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for trans-Ned 19
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for trans-Ned 19
The following data is based on the product molecular weight 514.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.94 mL||9.72 mL||19.43 mL|
|5 mM||0.39 mL||1.94 mL||3.89 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References for trans-Ned 19
References are publications that support the biological activity of the product.
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220 PMID: 19234453
Rosen et al (2009) Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J.Biol.Chem. 284 34930 PMID: 19826006
Thai et al (2009) NAADP receptors mediate calcium signaling stimulated by endothelin-1 and NE in renal afferent arterioles. Am.J.Physiol.Renal Physiol. 297 F510 PMID: 19439521
If you know of a relevant reference for trans-Ned 19, please let us know.
Keywords: trans-Ned 19, trans-Ned 19 supplier, NAAPD, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, ned19, General, Calcium, Signaling, Agents, 3954, Tocris Bioscience
6 Citations for trans-Ned 19
Citations are publications that use Tocris products. Selected citations for trans-Ned 19 include:
Zhuo et al (2021) TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. Life Sci Alliance 4 PMID: 34183443
Simon P et al (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. Elife 10 PMID: 34677124
Favia et al (2016) NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Toxicol Lett 6 18925 PMID: 26733361
Joe et al (2020) Cross-talk between CD38 and TTP is essential for resolution of inflammation during microbial sepsis. Cell Rep. 30 1063 PMID: 31995750
Olimpia et al (2023) Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death. NeuroImmune Pharm Ther 2 19-35 PMID: 37027339
Petr et al (2020) Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis. Biomolecules 10 PMID: 31947839
Do you know of a great paper that uses trans-Ned 19 from Tocris? Please let us know.
Reviews for trans-Ned 19
There are currently no reviews for this product. Be the first to review trans-Ned 19 and earn rewards!
Have you used trans-Ned 19?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image