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trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 514.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.94 mL||9.72 mL||19.43 mL|
|5 mM||0.39 mL||1.94 mL||3.89 mL|
|10 mM||0.19 mL||0.97 mL||1.94 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References are publications that support the biological activity of the product.
Naylor et al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220 PMID: 19234453
Rosen et al (2009) Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J.Biol.Chem. 284 34930 PMID: 19826006
Thai et al (2009) NAADP receptors mediate calcium signaling stimulated by endothelin-1 and NE in renal afferent arterioles. Am.J.Physiol.Renal Physiol. 297 F510 PMID: 19439521
If you know of a relevant reference for trans-Ned 19, please let us know.
Keywords: trans-Ned 19, trans-Ned 19 supplier, NAAPD, nicotinic, acid, adenine, dinucleotide, phosphate, antagonists, calcium, signaling, signalling, inhibitors, inhibits, fluorescent, ned19, General, Calcium, Signaling, Agents, Probes, and, Ca2+, Indicator, Dyes, 3954, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for trans-Ned 19 include:
Joe et al (2020) Cross-talk between CD38 and TTP is essential for resolution of inflammation during microbial sepsis. Cell Rep. 30 1063 PMID: 31995750
Favia et al (2016) NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Toxicol Lett 6 18925 PMID: 26733361
Do you know of a great paper that uses trans-Ned 19 from Tocris? Please let us know.
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