Torcetrapib

Pricing Availability   Qty
Cat.No. 4184 - Torcetrapib | C26H25F9N2O4 | CAS No. 262352-17-0
Description: Inhibitor of cholesteryl ester transfer protein (CETP)
Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Torcetrapib is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 600.47
Formula C26H25F9N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 262352-17-0
PubChem ID 159325
InChI Key CMSGWTNRGKRWGS-NQIIRXRSSA-N
Smiles CC[C@H]2N(C(OCC)=O)C1=CC=C(C(F)(F)F)C=C1[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 600.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.33 mL 16.65 mL 33.31 mL
2.5 mM 0.67 mL 3.33 mL 6.66 mL
5 mM 0.33 mL 1.67 mL 3.33 mL
25 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459 PMID: 20051879

Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465 PMID: 18536749


If you know of a relevant reference for Torcetrapib, please let us know.

View Related Products by Product Action

View all Other Transferase Inhibitors

Keywords: Torcetrapib, Torcetrapib supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Other, Transferases, Lipid, Metabolism, 4184, Tocris Bioscience

Citations for Torcetrapib

Citations are publications that use Tocris products.

Currently there are no citations for Torcetrapib. Do you know of a great paper that uses Torcetrapib from Tocris? Please let us know.

Reviews for Torcetrapib

There are currently no reviews for this product. Be the first to review Torcetrapib and earn rewards!

Have you used Torcetrapib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells