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Cat.No. 4184 - Torcetrapib | C26H25F9N2O4 | CAS No. 262352-17-0
Description: Inhibitor of cholesteryl ester transfer protein (CETP)
Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)

Biological Activity for Torcetrapib

Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Torcetrapib

M. Wt 600.47
Formula C26H25F9N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 262352-17-0
PubChem ID 159325
Smiles CC[C@H]2N(C(OCC)=O)C1=CC=C(C(F)(F)F)C=C1[C@@H](N(CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(OC)=O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Torcetrapib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.02 50

Preparing Stock Solutions for Torcetrapib

The following data is based on the product molecular weight 600.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.33 mL 16.65 mL 33.31 mL
2.5 mM 0.67 mL 3.33 mL 6.66 mL
5 mM 0.33 mL 1.67 mL 3.33 mL
25 mM 0.07 mL 0.33 mL 0.67 mL

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References for Torcetrapib

References are publications that support the biological activity of the product.

Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459 PMID: 20051879

Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465 PMID: 18536749

If you know of a relevant reference for Torcetrapib, please let us know.

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Keywords: Torcetrapib, Torcetrapib supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Other, Transferases, Lipid, Metabolism, 4184, Tocris Bioscience

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