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Biological Activity for Torcetrapib
Torcetrapib is an inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Torcetrapib
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Torcetrapib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Torcetrapib
The following data is based on the product molecular weight 600.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.33 mL||16.65 mL||33.31 mL|
|2.5 mM||0.67 mL||3.33 mL||6.66 mL|
|5 mM||0.33 mL||1.67 mL||3.33 mL|
|25 mM||0.07 mL||0.33 mL||0.67 mL|
References for Torcetrapib
References are publications that support the biological activity of the product.
Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459 PMID: 20051879
Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465 PMID: 18536749
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Keywords: Torcetrapib, Torcetrapib supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Other, Transferases, Lipid, Metabolism, 4184, Tocris Bioscience
Citations for Torcetrapib
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