Tolterodine L-tartrate

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Cat.No. 3761 - Tolterodine L-tartrate | C22H31NO.C4H6O6 | CAS No. 124937-52-6
Description: Potent, non-selective muscarinic receptor antagonist
Chemical Name: 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (2R,3R)-2,3-dihydroxybutanedioate
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity

High affinity muscarinic receptor antagonist (Ki = 3.3 nM). Active at all muscarinic receptor subtypes (M1 - M5); exhibits a greater effect on the bladder than salivary glands in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Tolterodine L-tartrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 475.57
Formula C22H31NO.C4H6O6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 124937-52-6
PubChem ID 443878
Smiles OC1=C([C@@H]([C@]2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(C)C=C1.OC([C@H](O)[C@@H](O)C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.76 10
DMSO 47.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 475.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.51 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References are publications that support the biological activity of the product.

Nilvebrant et al (1997) Tolterodine - a new bladder-selective antimuscarinic agent. Eur.J.Pharmacol. 327 195 PMID: 9200560

Nilvebrant (2001) Clinical experiences with tolter. Life Sci. 68 2549 PMID: 11392625

If you know of a relevant reference for Tolterodine L-tartrate, please let us know.

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