Tolcapone

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Cat.No. 5864 - Tolcapone | C14H11NO5 | CAS No. 134308-13-7
Description: COMT inhibitor; also inhibits transthyretin aggregation
Alternative Names: Tasmar, Ro 40-7592
Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.

Technical Data

M. Wt 273.24
Formula C14H11NO5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 134308-13-7
PubChem ID 4659569
InChI Key MIQPIUSUKVNLNT-UHFFFAOYSA-N
Smiles OC1=C(O)C([N+]([O-])=O)=CC(C(C2=CC=C(C)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.32 100
ethanol 27.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sant'Anna et al (2016) Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nat.Commun. 7 10787 PMID: 26902880

Männistö et al (1992) Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. Br.J.Pharmacol. 105 569 PMID: 1628144


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Keywords: Tolcapone, supplier, catechol, O-methyl, transferase, inhibitors, inhibits, COMT, orally, bioavailable, high, affinity, TTR, binding, transthyretin, aggregation, Ro40-7592, Tasmar, Ro, 40-7592, Catechol, O-Methyltransferase, Catechol, O-Methyltransferase, Tocris Bioscience

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