Tocriscreen Epigenetics Toolbox

Description: 80 Epigenetic modulators supplied pre-dissolved in DMSO (250 μL 10 mM solutions)
Datasheet
Citations (1)
Reviews
Literature (9)

Biological Activity

A collection of 80 chemical modulators for Epigenetics Research supplied as pre-dissolved DMSO solutions (250 μl 10 mM solution per compound).

This toolbox has been replaced by the Tocriscreen Epigenetics Library (Cat. No. 6801).

Key Format and Product Details

  • 96-well rack with Matrix storage tubes & SepraSeal caps
  • Pre-dissolved in DMSO
  • All compounds are biologically active
  • Many compounds are exclusive to Tocris
  • Full chemical and biological data available
  • Exceptional purity

Technical Data

Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References

References are publications that support the biological activity of the product.

Keywords: Tocriscreen Epigenetics Toolbox, Tocriscreen Epigenetics Toolbox supplier, Tocriscreens, Epigenetics, Toolbox, compounds, libraries, library, screening, tools, histones, readers, writers, erasers, bromodomains, BET, BRD, DNA, methyltransferases, HMTs, MBT, L3MBT, RNA, polymerases, demethylases, HDMs, acetyltransferases, HATs, deacetylases, HDACS, KDMs, modu, Tocriscreen, Toolboxes, 5268, Tocris Bioscience

1 Citation for Tocriscreen Epigenetics Toolbox

Citations are publications that use Tocris products. Selected citations for Tocriscreen Epigenetics Toolbox include:

Andricovich (2018) Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors. Cancer Cell 33 512 PMID: 29533787


Reviews for Tocriscreen Epigenetics Toolbox

There are currently no reviews for this product. Be the first to review Tocriscreen Epigenetics Toolbox and earn rewards!

Have you used Tocriscreen Epigenetics Toolbox?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Compound Libraries & Toolboxes

Compound Libraries & Toolboxes

This brochure gives an overview of the unique TocriscreenTM compound libraries and toolboxes available from Tocris, including the Tocriscreen Plus, and toolboxes for the study of epigenetics, kinases and stem cells.

  • Tocriscreen Plus & Plus Mini
  • Custom Libraries
  • FDA-Approved Compounds
  • Tocriscreen Toolboxes
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Epigenetics in Cancer

Epigenetics in Cancer Poster

Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Stem Cell Workflow

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.