Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
TM N1324 is a potent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.98||10 with gentle warming|
The following data is based on the product molecular weight 397.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.14 mL||125.69 mL||251.39 mL|
|0.5 mM||5.03 mL||25.14 mL||50.28 mL|
|1 mM||2.51 mL||12.57 mL||25.14 mL|
|5 mM||0.5 mL||2.51 mL||5.03 mL|
References are publications that support the biological activity of the product.
Frimurer et al (2017) Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions. J.Med.Chem. 60 886 PMID: 28045522
If you know of a relevant reference for TM N1324, please let us know.
Keywords: TM N1324, TM N1324 supplier, TMN1324, gpr39, agonists, agonism, potent, selective, orally, bioavailable, cell, permeable, zn2+, zinc, Orphan, 7-TM, Receptors, 6325, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for TM N1324. Do you know of a great paper that uses TM N1324 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review TM N1324 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.