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Submit ReviewTM N1324
Description: Potent and selective GPR39 agonist; orally bioavailable
Chemical Name: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one
Purity: ≥98% (HPLC)
Biological Activity for TM N1324
TM N1324 is a potent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.
Technical Data for TM N1324
| M. Wt | 397.79 |
| Formula | C18H13ClFN7O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1144477-35-9 |
| PubChem ID | 42654322 |
| InChI Key | AAKZKVKEKKTMRJ-UHFFFAOYSA-N |
| Smiles | CC1=NN(C2=C3NC=NC3=NC=N2)C4=C1C(C5=C(C=C(C=C5)F)Cl)CC(N4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TM N1324
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.98 | 10 with gentle warming |
Preparing Stock Solutions for TM N1324
The following data is based on the product molecular weight 397.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.14 mL | 125.69 mL | 251.39 mL |
| 0.5 mM | 5.03 mL | 25.14 mL | 50.28 mL |
| 1 mM | 2.51 mL | 12.57 mL | 25.14 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.03 mL |
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Product Datasheets for TM N1324
References for TM N1324
References are publications that support the biological activity of the product.
Frimurer et al (2017) Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions. J.Med.Chem. 60 886 PMID: 28045522
If you know of a relevant reference for TM N1324, please let us know.
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Keywords: TM N1324, TM N1324 supplier, TMN1324, gpr39, agonists, agonism, potent, selective, orally, bioavailable, cell, permeable, zn2+, zinc, Orphan, 7-TM, Receptors, 6325, Tocris Bioscience
Citations for TM N1324
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GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling