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Biological Activity for TM N1324
TM N1324 is a potent and selective GPR39 agonist (IC50 values are 280 and 9 nM in the absence and presence of Zn2+, respectively). Exhibits no significant activity against a panel of 165 other GPCRs. Inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Cell permeable and orally bioavailable.
Technical Data for TM N1324
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for TM N1324
References are publications that support the biological activity of the product.
Frimurer et al (2017) Model-based discovery of synthetic agonists for the Zn2+-sensing G-protein-coupled receptor 39 (GPR39) reveals novel biological functions. J.Med.Chem. 60 886 PMID: 28045522
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Keywords: TM N1324, TM N1324 supplier, TMN1324, gpr39, agonists, agonism, potent, selective, orally, bioavailable, cell, permeable, zn2+, zinc, Orphan, 7-TM, Receptors, 6325, Tocris Bioscience
Citations for TM N1324
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Currently there are no citations for TM N1324.
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