Thrombin Receptor Agonist Peptide

Pricing Availability Delivery Time Qty
Cat.No. 1185 - Thrombin Receptor Agonist Peptide | Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe | CAS No. 137339-65-2
Description: Causes platelet aggregation and secretion
Alternative Names: TRAP
Datasheet
Citations (2)
Literature

Biological Activity

Agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.

Technical Data

M. Wt 1739
Formula C81H118N20O23
Sequence SFLLRNPNDKYEPF
Storage Desiccate at -20°C
CAS Number 137339-65-2
PubChem ID 16131180
InChI Key OXHYRVSBKWIFES-WWSDOYNLSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.90 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1739. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.88 mL 5.75 mL
5 mM 0.12 mL 0.58 mL 1.15 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435 PMID: 1655750

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429

Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057 PMID: 1672265


If you know of a relevant reference for Thrombin Receptor Agonist Peptide, please let us know.

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Keywords: Causes platelet aggregation secretion PAR Receptors Protease-Activated thrombin receptor agonists TRAP Protease-Activated Receptors

2 Citations for Thrombin Receptor Agonist Peptide

Citations are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:

White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Endocrinol 194 142 PMID: 25429068

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278


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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for Thrombin Receptor Agonist Peptide

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