Thrombin Receptor Agonist Peptide
Agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.90 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1739. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.58 mL||2.88 mL||5.75 mL|
|5 mM||0.12 mL||0.58 mL||1.15 mL|
|10 mM||0.06 mL||0.29 mL||0.58 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the biological activity of the product.
Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435 PMID: 1655750
Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429
Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057 PMID: 1672265
If you know of a relevant reference for Thrombin Receptor Agonist Peptide, please let us know.
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Keywords: Thrombin Receptor Agonist Peptide, Thrombin Receptor Agonist Peptide supplier, Causes, platelet, aggregation, secretion, PAR, Receptors, Protease-Activated, thrombin, receptor, agonists, TRAP, 1185, Tocris Bioscience
2 Citations for Thrombin Receptor Agonist Peptide
Citations are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Endocrinol 194 142 PMID: 25429068
Do you know of a great paper that uses Thrombin Receptor Agonist Peptide from Tocris? Please let us know.
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Literature in this Area
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