Thrombin Receptor Agonist Peptide

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Description: Causes platelet aggregation and secretion
Alternative Names: TRAP
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Thrombin Receptor Agonist Peptide

Thrombin Receptor Agonist Peptide is an agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.

Technical Data for Thrombin Receptor Agonist Peptide

M. Wt 1739
Formula C81H118N20O23
Sequence SFLLRNPNDKYEPF
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 137339-65-2
PubChem ID 16131180
InChI Key OXHYRVSBKWIFES-WWSDOYNLSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Thrombin Receptor Agonist Peptide

Solubility Soluble to 0.90 mg/ml in water

Product Datasheets for Thrombin Receptor Agonist Peptide

Certificate of Analysis / Product Datasheet
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References for Thrombin Receptor Agonist Peptide

References are publications that support the biological activity of the product.

Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435 PMID: 1655750

Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429

Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057 PMID: 1672265


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Keywords: Thrombin Receptor Agonist Peptide, Thrombin Receptor Agonist Peptide supplier, Causes, platelet, aggregation, secretion, PAR, Receptors, Protease-Activated, thrombin, receptor, agonists, TRAP, 1185, Tocris Bioscience

2 Citations for Thrombin Receptor Agonist Peptide

Citations are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:

White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Endocrinol 194 142 PMID: 25429068

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278


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