TH 588

Pricing Availability   Qty
Description: Potent MTH1 inhibitor
Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for TH 588

TH 588 is a potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Technical Data for TH 588

M. Wt 295.17
Formula C13H12Cl2N4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1609960-31-7
PubChem ID 73389731
Smiles NC1=NC(C2=C(Cl)C(Cl)=CC=C2)=CC(NC3CC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TH 588

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.52 100

Preparing Stock Solutions for TH 588

The following data is based on the product molecular weight 295.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.94 mL 33.88 mL
5 mM 0.68 mL 3.39 mL 6.78 mL
10 mM 0.34 mL 1.69 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for TH 588

References are publications that support the biological activity of the product.

Gad et al (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508 215 PMID: 24695224

If you know of a relevant reference for TH 588, please let us know.

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Citations for TH 588

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.