Potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 295.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.39 mL||16.94 mL||33.88 mL|
|5 mM||0.68 mL||3.39 mL||6.78 mL|
|10 mM||0.34 mL||1.69 mL||3.39 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the products' biological activity.
Gad et al (2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508 215 PMID: 24695224
If you know of a relevant reference for TH 588, please let us know.
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Keywords: TH 588, supplier, TH588, MTH1, MutT, homolog-1, inhibitors, inhibits, potent, MutT, homolog-1, (MTH1), MutT, homolog-1, (MTH1), Tocris Bioscience
Citations for TH 588
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