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Biological Activity for TG 4-155
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Technical Data for TG 4-155
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for TG 4-155
References are publications that support the biological activity of the product.
Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657
Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506
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Keywords: TG 4-155, TG 4-155 supplier, TG4-155, high, affinity, selective, EP2, prostanoid, receptors, antagonists, Prostanoid, Receptors, 5052, Tocris Bioscience
2 Citations for TG 4-155
Citations are publications that use Tocris products. Selected citations for TG 4-155 include:
Donna A et al (2020) Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells. Front Immunol 11 143 PMID: 32158443
Cuesto et al (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS One 10 e0118475 PMID: 25764078
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