TG 4-155

Pricing Availability Delivery Time Qty
Cat.No. 5052 - TG 4-155 | C23H26N2O4 | CAS No. 1164462-05-8
Description: High affinity and selective EP2 receptor antagonist
Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.

Technical Data

M. Wt 394.46
Formula C23H26N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1164462-05-8
PubChem ID 5886965
InChI Key YBHUXHFZLMFETJ-MDZDMXLPSA-N
Smiles CC2=CC1=CC=CC=C1N2CCNC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100
ethanol 7.89 20

Preparing Stock Solutions

The following data is based on the product molecular weight 394.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657

Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506


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Citations for TG 4-155

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Pathways for TG 4-155

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