You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for TG 4-155
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5 nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Technical Data for TG 4-155
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TG 4-155
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TG 4-155
The following data is based on the product molecular weight 394.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.68 mL||25.35 mL|
|5 mM||0.51 mL||2.54 mL||5.07 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References for TG 4-155
References are publications that support the biological activity of the product.
Jiang and Dingledine (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J.Pharmacol.Exp.Ther. 344 360 PMID: 23192657
Quan et al (2013) EP2 receptor signaling pathways regulate classical activation of microglia. J.Biol.Chem. 288 9293 PMID: 23404506
If you know of a relevant reference for TG 4-155, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TG 4-155, TG 4-155 supplier, TG4-155, high, affinity, selective, EP2, prostanoid, receptors, antagonists, Prostanoid, Receptors, 5052, Tocris Bioscience
1 Citation for TG 4-155
Citations are publications that use Tocris products. Selected citations for TG 4-155 include:
Cuesto et al (2015) GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS One 10 e0118475 PMID: 25764078
Do you know of a great paper that uses TG 4-155 from Tocris? Please let us know.
Reviews for TG 4-155
There are currently no reviews for this product. Be the first to review TG 4-155 and earn rewards!
Have you used TG 4-155?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.