Pricing Availability   Qty
Description: PAR3 peptide agonist
Purity: ≥95% (HPLC)

Biological Activity for TFRGAP-NH2

TFRGAP-NH2 is a protease-activated receptor 3 (PAR3) peptide agonist. In vitro, it increases the expression of heme oxygenase (HO)-1 in osteoarthritis synovial fibroblasts (OASFs).

Technical Data for TFRGAP-NH2

M. Wt 646.75
Formula C29H46N10O7
Sequence TFRGAP

(Modification: Pro-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1872435-09-0
PubChem ID 162678814
Smiles O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C)C(N2[C@@H](CCC2)C(N)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TFRGAP-NH2

Solubility Soluble to 1 mg/ml in water

References for TFRGAP-NH2

References are publications that support the biological activity of the product.

Subramaniam et al (2021) A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 5 2760 PMID: 34242391

Yu et al (2021) Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell Death Discov. 7 343 PMID: 34753916

Iyer et al (2021) PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Front Physiol. 12 615428 PMID: 33776786

Mogami et al (2014) Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J.Biol.Chem. 289 13295 PMID: 24652285

Lin et al (2006) c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. J.Immunol. 177 3427 PMID: 16920985

Liu et al (2012) Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways. Arthritis Res.Ther. 14 R91 PMID: 22541814

If you know of a relevant reference for TFRGAP-NH2, please let us know.

View Related Products by Product Action

View all Protease-Activated Receptor Agonists

Keywords: TFRGAP-NH2, TFRGAP-NH2 supplier, TFRGAPNH2, PAR3, activating, peptides, PAR, Receptors, Proteases, Activated, proteinases, activated, Protease-Activated, 7742, Tocris Bioscience

Citations for TFRGAP-NH2

Citations are publications that use Tocris products.

Currently there are no citations for TFRGAP-NH2. Do you know of a great paper that uses TFRGAP-NH2 from Tocris? Please let us know.

Reviews for TFRGAP-NH2

There are currently no reviews for this product. Be the first to review TFRGAP-NH2 and earn rewards!

Have you used TFRGAP-NH2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review