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Biological Activity for TFRGAP-NH2
TFRGAP-NH2 is a protease-activated receptor 3 (PAR3) peptide agonist. In vitro, it increases the expression of heme oxygenase (HO)-1 in osteoarthritis synovial fibroblasts (OASFs).
Technical Data for TFRGAP-NH2
(Modification: Pro-6 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TFRGAP-NH2
|Solubility||Soluble to 1 mg/ml in water|
References for TFRGAP-NH2
References are publications that support the biological activity of the product.
Subramaniam et al (2021) A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 5 2760 PMID: 34242391
Yu et al (2021) Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role. Cell Death Discov. 7 343 PMID: 34753916
Iyer et al (2021) PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Front Physiol. 12 615428 PMID: 33776786
Mogami et al (2014) Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J.Biol.Chem. 289 13295 PMID: 24652285
Lin et al (2006) c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. J.Immunol. 177 3427 PMID: 16920985
Liu et al (2012) Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways. Arthritis Res.Ther. 14 R91 PMID: 22541814
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Citations for TFRGAP-NH2
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Currently there are no citations for TFRGAP-NH2. Do you know of a great paper that uses TFRGAP-NH2 from Tocris? Please let us know.
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